What product is formed when the given compound is treated with NaH? The given acid-base reactions...
Question:
What product is formed when the given compound is treated with NaH? The given acid-base reactions were a step in a synthesis of a commercially available drug.
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Acid-base reaction:
In an acid-base chemical reaction, both acid (RCOOH) and the base act as reactants. In this reaction, the acid compound and the base compound are mixed together, and they exchange one or more hydrogen (H) atoms to form a conjugated acid or conjugated base as a product.
Answer and Explanation: 1
In the chemical reaction, the base abstracts the highly acidic proton ({eq}\rm H^{+}{/eq} ) from the given compound. The proton which is attached to the high electronegative (EN) atom will be most acidic, and this proton will get abstracted first in the presence of base sodium hydride (NaH).
The acid-base reaction of the given (E)-N-(3-(3-(dimethylamino)acryloyl)phenyl)acetamide compound and the ion produced is shown below.
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Here, in the given compound, proton attached to the nitrogen (N) atom is abstracted first, and then the negative charge is stabilized by resonance.
Learn more about this topic:
from
Chapter 10 / Lesson 5Learn about acid-base neutralization reactions. Understand the reaction between acid and base, the neutralization reaction, the definition, and see the products.