What carbonyl compounds might you start with to prepare the following compounds by Grignard...
Question:
What carbonyl compounds might you start with to prepare the following compounds by Grignard reaction? List all possibilities.
- a) 2-methyl-2propanal
- b) 1-ethylcyclohexanol
- c) 3-phenyl-3-pentanol
- d) 2-phenyl-2-pentanol
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Grignard Reaction
The Grignard reagent is formed by reacting an organomagnesium compound with haloalkane in ether solvent. The carbon atom of a Grignard reagent bears a partial negative charge and acts as a good nucleophile. Generally, Grignard reagents react with carbonyl compounds (aldehyde or ketone) to form alcohols.
- When reacted with formaldehyde, a primary alcohol is formed.
- When reacted with other aldehydes, secondary alcohols are formed.
- When reacted with ketones, tertiary alcohols are formed.
Answer and Explanation: 1
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View this answerThe following carbonyl compounds and Grignard reagents are needed to form alcohols:
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Grignard Reaction with Alcohol, Ketone & Aldehyde
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Chapter 10 / Lesson 28
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Learn about Grignard reactions with alcohol, ketone, and aldehyde. Study their mechanism and product, and discover which Grignard reaction turns ketone to alcohol.
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