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How does the immune process that causes hemolytic disease of the newborn take place?

Question:

How does the immune process that causes hemolytic disease of the newborn take place?

Hemolytic Disease:

Hemolytic disease of the newborn (HDN), also known as erythroblastosis fetalis (immature blood cells in the fetus), is a blood-related disorder in infants. It happens when a newborn child's red blood cells break down at a rate faster than the RBC formation rate. Typically, red blood cells (RBCs) keep going for around 120 days in the body, but in this disorder, RBCs in the blood are obliterated rapidly and subsequently don't keep going as long.

Answer and Explanation: 1

All individuals have a blood classification (A, B, AB, or O) also an Rh factor (positive or negative). There can be an issue if a mother and child have a varying blood classification and Rh factor. HDN happens at birth when the placenta breaks and it occurs regularly when an Rh-negative mother has a child with an Rh-positive dad. If the child's Rh factor is positive, similar to their father's, this can be an issue if the newborn's red blood cells cross to the Rh-negative mother.

During pregnancy, RBCs from the unborn child can get into the mother's blood through the placenta. HDN happens when the immune framework of the mother considers the baby's RBCs as unfamiliar or foreign molecules. Antibodies, at that point, are created against the child's RBCs and these antibodies assault the RBCs in the child's blood and cause them to break down too soon.


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Rh Blood Group, Rh Factor & Erythroblastosis Fetalis

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Chapter 13 / Lesson 6
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The Rh blood group system is a classification system for blood based on the presence or absence of Rh antigen. Individuals who possess the Rh antigen are considered Rh positive, whereas individuals who do not carry the antigen are considered Rh negative. Learn about blood groups, the Rh blood group system, Rh negative blood, and the effect of Rh factor in erythroblastosis fetalis.


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